Rabbit monoclonal to Histone H3 K27M;
Histone H3, K27M Mutant;

100 -k27m-rabbit-monoclonal-antibody-clone-rm192-histone-h3-k27m-mutant/" method="post" enctype='multipart/form-data' data-product_id="6393" data-product_variations="[{"attributes":{"attribute_conjugation":"Unconjugated","attribute_size-format":"100 \u00b5L"},"availability_html":"","backorders_allowed":false,"dimensions":{"length":"","width":"","height":""},"dimensions_html":"N\/A","display_price":373,"display_regular_price":373,"image":{"title":"Fig1 RM192 K27M_Brandner_POS","caption":"","url":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","alt":"Fig1 RM192 K27M_Brandner_POS","src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png","srcset":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png 510w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-300x292.png 300w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png 247w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png 591w","sizes":"(max-width: 510px) 100vw, 510px","full_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","full_src_w":591,"full_src_h":575,"gallery_thumbnail_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-100x100.png","gallery_thumbnail_src_w":100,"gallery_thumbnail_src_h":100,"thumb_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png","thumb_src_w":247,"thumb_src_h":240,"src_w":510,"src_h":496},"image_id":12727,"is_downloadable":false,"is_in_stock":true,"is_purchasable":true,"is_sold_individually":"no","is_virtual":false,"max_qty":"","min_qty":1,"price_html":"<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>373.00<\/bdi><\/span><\/span>","sku":"31-1175-00-S","variation_description":"","variation_id":9501,"variation_is_active":true,"variation_is_visible":true,"weight":"","weight_html":"N\/A"},{"attributes":{"attribute_conjugation":"Unconjugated","attribute_size-format":"400 \u00b5L"},"availability_html":"","backorders_allowed":false,"dimensions":{"length":"","width":"","height":""},"dimensions_html":"N\/A","display_price":907,"display_regular_price":907,"image":{"title":"Fig1 RM192 K27M_Brandner_POS","caption":"","url":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","alt":"Fig1 RM192 K27M_Brandner_POS","src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png","srcset":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png 510w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-300x292.png 300w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png 247w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png 591w","sizes":"(max-width: 510px) 100vw, 510px","full_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","full_src_w":591,"full_src_h":575,"gallery_thumbnail_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-100x100.png","gallery_thumbnail_src_w":100,"gallery_thumbnail_src_h":100,"thumb_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png","thumb_src_w":247,"thumb_src_h":240,"src_w":510,"src_h":496},"image_id":12727,"is_downloadable":false,"is_in_stock":true,"is_purchasable":true,"is_sold_individually":"no","is_virtual":false,"max_qty":"","min_qty":1,"price_html":"<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>907.00<\/bdi><\/span><\/span>","sku":"31-1175-00-L","variation_description":"","variation_id":9502,"variation_is_active":true,"variation_is_visible":true,"weight":"","weight_html":"N\/A"},{"attributes":{"attribute_conjugation":"Biotin Conjugate","attribute_size-format":"50 \u00b5L"},"availability_html":"","backorders_allowed":false,"dimensions":{"length":"","width":"","height":""},"dimensions_html":"N\/A","display_price":373,"display_regular_price":373,"image":{"title":"Fig1 RM192 K27M_Brandner_POS","caption":"","url":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","alt":"Fig1 RM192 K27M_Brandner_POS","src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png","srcset":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-510x496.png 510w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-300x292.png 300w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png 247w, https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png 591w","sizes":"(max-width: 510px) 100vw, 510px","full_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1.png","full_src_w":591,"full_src_h":575,"gallery_thumbnail_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-100x100.png","gallery_thumbnail_src_w":100,"gallery_thumbnail_src_h":100,"thumb_src":"https:\/\/www.revmab.com\/wp-content\/uploads\/2021\/05\/Fig1-RM192-K27M_Brandner_POS-1-247x240.png","thumb_src_w":247,"thumb_src_h":240,"src_w":510,"src_h":496},"image_id":12727,"is_downloadable":false,"is_in_stock":true,"is_purchasable":true,"is_sold_individually":"no","is_virtual":false,"max_qty":"","min_qty":1,"price_html":"<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>373.00<\/bdi><\/span><\/span>","sku":"31-1175-02","variation_description":"","variation_id":12327,"variation_is_active":true,"variation_is_visible":true,"weight":"","weight_html":"N\/A"}]">

Conjugation

Choose an optionUnconjugatedBiotin Conjugate

Size format

Choose an optionAnti-Histone H3 K27M Rabbit Monoclonal Antibody [Clone RM192]; Histone H3, K27M Mutant; 31-1175-00-S; 31-1175-00-L; 31-1175-02 quantity Add to cart Add to Wishlist Product Details Product Name Anti-Histone H3 K27M Rabbit Monoclonal Antibody, Clone RM192 Product Description Rabbit monoclonal to Histone H3 K27M; Histone H3, K27M Mutant Catalog No. 31-1175-00-S; 31-1175-00-L; 31-1175-02 Clone Name RM192 Product Data Sheet Anti-Histone H3 K27M Rabbit Monoclonal Antibody Data Sheet RM192 Biotinylated Anti-Histone H3 K27M Rabbit Monoclonal Antibody Data Sheet RM192 Specificity RM192 reacts to the Histone H3 K27M mutant. No cross reactivity with wild type Histone H3. Immunogen A peptide corresponding to Histone H3 K27M mutant Application Western Blot ELISA Immunohistochemistry Species Reactivity All Conjugate None Intended Use Research Use Only . Properties Form Liquid Storage Instructions Store at -20.0"> Stability Stable for 1 Year at -20.0"> Storage Buffer 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide Volume/Size 100 "> Purity Protein A affinity purified from an animal origin"> Clone Type Monoclonal Isotype Rabbit IgG Usage Western Blot: 1:250 :2500; ELISA: 1:250 :2500; IHC: 1:100 :500. References for Histone H3 K27M Mutant antibody [RM192] Thomas L et al OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. J Transl Med. (2020), 10.1186/s12967-020-02593-5. IHC; Human. Read more (PubMed: 33168005) Minasi S et al Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma. Childs Nerc Syst. (2020), 10.1007/s00381-020-04933-8. IHC; Human. Read more (PubMed: 33128602) Mondal G et al Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. Acta Neuropathol. (2020), 10.1007/s00401-020-02155-5. IHC; Human. Read more (PubMed: 32303840) Maeda S et al H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant. Acta Neuropathol Commun. (2020), 10.1186/s40478-020-0882-4. WB, IHC; Human. Read more (PubMed: 32019606) Chiang J et al Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG. Acta Neuropathol Commun. (2020), 10.1186/s40478-020-00930-9. IHC; Human. Read more (PubMed: 32326973) Tanrıkulu B et al. Is H3K27me3 status really a strong prognostic indicator for pediatric posterior fossa ependymomas? A single surgeon, single center experience. Childs Nerv Syst. (2020), 10.1007/s00381-020-04518-5. IHC-F; Human. Read more (PubMed: 32025869) Qiu T et al. Imaging characteristics of adult H3 K27M-mutant gliomas. J Neurosurg. (2019), 10.3171/2019.9.JNS191920. IHC; Human. Read more (PubMed: 31731269) Pathania M et al. H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas Cancer Cell (2017) 10.1016/j.ccell.2017.09.014. IHC-P; Human. Read more (PubMed: 29107533) . Product Images Immunostaining of brain tumor tissue sections using both EDTA and Citrate pretreatment methods. Clinically validated to be Positive for the H3.3 K27M Mutation by Sanger sequencing. Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Immunostaining of brain tumor tissue sections using both EDTA and Citrate pretreatment methods. Clinically validated to be Negative for the H3.3 K27M Mutation by Sanger sequencing. Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Immunohistochemical staining of formalin fixed and paraffin embedded 293T cells transfected with a DNA construct encoding Histone H3 K27M mutant, stained with 0.01 K27M rabbit monoclonal antibody, Clone RM192. Vous serez peut-être également intéressé par les produits suivants : 10 20 50 100 200 500   Référence Description Cond. Prix HT Ce produit ne peut pas être commandé depuis votre catalogue électronique. Un devis va être créer pour cette référence, souhaitez-vous continuer ? Assurez-vous dans ce cas d'avoir bien rempli la quantité souhaité E-mail