Anti-VGluT1 antibody (1-50) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Slc17a7
Gene ID:	72961
Uniprot ID:	VGLU1_MOUSE
Immunogen Region:	1-50
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on mouse Vesicular Glutamate transporter 1 protein.

Tissue Specificity	Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina.
Function	Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake. The vesicular K(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic. Is necessary for synaptic signaling of visual-evoked responses from photoreceptors.
Protein Name	Vesicular Glutamate Transporter 1 Vglut1 Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter Solute Carrier Family 17 Member 7
Database Links	Reactome: R-MMU-210500 Reactome: -MMU-428643
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Cell Membrane Multi-Pass Membrane Protein Synapse Synaptosome
Alternative Antibody Names	Anti-Vesicular Glutamate Transporter 1 antibody Anti-Vglut1 antibody Anti-Brain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter antibody Anti-Solute Carrier Family 17 Member 7 antibody Anti-Slc17a7 antibody Anti-Bnpi antibody Anti-Vglut1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance