Azithromycin (hydrate) [117772-70-0]
Référence HY-17506A-50mg
Conditionnement : 50mg
Marque : MedChemExpress
Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
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Azithromycin hydrate Chemical Structure
CAS No. : 117772-70-0
This product is a controlled substance and not for sale in your territory.
Based on 24 publication(s) in Google Scholar
Other Forms of Azithromycin hydrate:
- Azithromycin In-stock
- Azithromycin-d3 Obtenir un devis
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Description |
Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. |
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IC50 & Target |
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In Vitro |
Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
785.02 |
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Formule |
C38H76N2O14 |
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CAS No. |
117772-70-0 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@@H]([C@@H]([C@@](C(O[C@@H]([C@@](C)(O)[C@@H]1O)CC)=O)(07)C)O[C@@](O[C@@H](C)[C@@H]2O)(07)C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN([C@@H]1C)C)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)(07)[C@@H]3O.O.O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (127.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Pureté et documentation |
Purity: ≥98.0% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.2739 mL | 6.3693 mL | 12.7385 mL | 31.8463 mL |
5 mM | 0.2548 mL | 1.2739 mL | 2.5477 mL | 6.3693 mL | |
10 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1846 mL | |
15 mM | 0.0849 mL | 0.4246 mL | 0.8492 mL | 2.1231 mL | |
20 mM | 0.0637 mL | 0.3185 mL | 0.6369 mL | 1.5923 mL | |
25 mM | 0.0510 mL | 0.2548 mL | 0.5095 mL | 1.2739 mL | |
30 mM | 0.0425 mL | 0.2123 mL | 0.4246 mL | 1.0615 mL | |
40 mM | 0.0318 mL | 0.1592 mL | 0.3185 mL | 0.7962 mL | |
50 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6369 mL | |
60 mM | 0.0212 mL | 0.1062 mL | 0.2123 mL | 0.5308 mL | |
80 mM | 0.0159 mL | 0.0796 mL | 0.1592 mL | 0.3981 mL | |
100 mM | 0.0127 mL | 0.0637 mL | 0.1274 mL | 0.3185 mL |
Azithromycin hydrate Related Classifications
- Anti-infection Autophagy
- Bacterial Autophagy Antibiotic Parasite