Blebbistatin
Référence M2459-5mg
Conditionnement : 5mg
Marque : AbMole Bioscience
All AbMole products are for research use only, cannot be used for human consumption.
(S)-(-)-Blebbistatin
Quality Control & Documentation
Biological Activity
Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.
*The compound is unstable in solutions, freshly prepared is recommended
Product Citations
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Lab Chip. 2023 Jul 7.
A microfluidic platform integrating dynamic cell culture and dielectrophoretic manipulation for in situ assessment of endothelial cell mechanics
(-)-Blebbistatin purchased from AbMole
Chemical Information
Molecular Weight | 292.33 |
Formula | C18H16N2O2 |
CAS Number | 856925-71-8 |
Solubility (25°C) | DMSO 10 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Wener Li, et al. Blebbistatin protects iPSC-CMs from hypercontraction and facilitates automated patch-clamp based electrophysiological study
[2] Song Gao, et al. Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells
[3] Yuanyuan Zhang, et al. An inhibitor of myosin II, blebbistatin, suppresses development of arterial thrombosis
[4] Anna Rauscher, et al. Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential
[5] Bart I Roman, et al. Medicinal Chemistry and Use of Myosin II Inhibitor ( S)-Blebbistatin and Its Derivatives