• Specifications

    Product Description

    Mouse monoclonal antibody raised against native CD46.

    Immunogen

    Native purified CD46 from human T cell line HPB-ALL.

    Host

    Mouse

    Theoretical MW (kDa)

    56-66

    Reactivity

    Bovine, Human

    Specificity

    This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 KDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.

    Form

    Liquid

    Conjugation

    APC

    Isotype

    IgG1

    Recommend Usage

    Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS (0.2% BSA, 0.09% sodium azide)

    Storage Instruction

    Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

    Immunoprecipitation

    Flow Cytometry

  • Gene Info — CD46

    Entrez GeneID

    4179

    Gene Name

    CD46

    Gene Alias

    MCP, MGC26544, MIC10, TLX, TRA2.10

    Gene Description

    CD46 molecule, complement regulatory protein

    Omim ID

    120920 235400

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    CD46 antigen, complement regulatory protein|OTTHUMP00000034577|OTTHUMP00000034622|OTTHUMP00000034623|OTTHUMP00000034624|OTTHUMP00000034625|OTTHUMP00000034626|OTTHUMP00000034706|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofacto

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