Clindamycin (hydrochloride) [21462-39-5]
Référence HY-B0408A-5g
Conditionnement : 5g
Marque : MedChemExpress
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
Clindamycin hydrochloride Chemical Structure
CAS No. : 21462-39-5
This product is a controlled substance and not for sale in your territory.
Based on 6 publication(s) in Google Scholar
Other Forms of Clindamycin hydrochloride:
- Clindamycin phosphate In-stock
- Clindamycin palmitate hydrochloride In-stock
- Clindamycin In-stock
- Clindamycin phosphate hydrochloride Obtenir un devis
- Clindamycin hydrochloride monohydrate Obtenir un devis
Description |
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
In Vitro |
Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
In Vivo |
Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Essai clinique |
|
||||||||||||
Masse moléculaire |
461.44 |
||||||||||||
Formule |
C18H34Cl2N2O5S |
||||||||||||
CAS No. |
21462-39-5 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
White to off-white |
||||||||||||
SMILES |
C[C@H](Cl)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)(22)O[C@@H]1SC)(22)NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl |
||||||||||||
Livraison | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
||||||||||||
Solvant et solubilité |
In Vitro:
DMSO : ≥ 100 mg/mL (216.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 100 mg/mL (216.71 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
|
||||||||||||
Pureté et documentation |
Purity: ≥98.0% |
||||||||||||
Références |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO / H2O | 1 mM | 2.1671 mL | 10.8356 mL | 21.6713 mL | 54.1782 mL |
5 mM | 0.4334 mL | 2.1671 mL | 4.3343 mL | 10.8356 mL | |
10 mM | 0.2167 mL | 1.0836 mL | 2.1671 mL | 5.4178 mL | |
15 mM | 0.1445 mL | 0.7224 mL | 1.4448 mL | 3.6119 mL | |
20 mM | 0.1084 mL | 0.5418 mL | 1.0836 mL | 2.7089 mL | |
25 mM | 0.0867 mL | 0.4334 mL | 0.8669 mL | 2.1671 mL | |
30 mM | 0.0722 mL | 0.3612 mL | 0.7224 mL | 1.8059 mL | |
40 mM | 0.0542 mL | 0.2709 mL | 0.5418 mL | 1.3545 mL | |
50 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0836 mL | |
60 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9030 mL | |
80 mM | 0.0271 mL | 0.1354 mL | 0.2709 mL | 0.6772 mL | |
100 mM | 0.0217 mL | 0.1084 mL | 0.2167 mL | 0.5418 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.