Duvelisib (R enantiomer) [1261590-48-0]
Référence HY-17044A-10mg
Conditionnement : 10mg
Marque : MedChemExpress
Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib.
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Duvelisib (R enantiomer) Chemical Structure
CAS No. : 1261590-48-0
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Duvelisib (R enantiomer):
- Duvelisib In-stock
Voir tous les produits spécifiques à Isoform PI3K:
Description |
Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib. |
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IC50 & Target[1] [1] |
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Masse moléculaire |
416.86 |
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Formule |
C22H17ClN6O |
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CAS No. |
1261590-48-0 |
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Appearance |
Solid |
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Color |
White to gray |
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SMILES |
ClC1=C(C2=O)C(C=C([C@H](NC3=NC=NC4=C3N=CN4)C)N2C5=CC=CC=C5)=CC=C1 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (239.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.3989 mL | 11.9944 mL | 23.9889 mL | 59.9722 mL |
5 mM | 0.4798 mL | 2.3989 mL | 4.7978 mL | 11.9944 mL | |
10 mM | 0.2399 mL | 1.1994 mL | 2.3989 mL | 5.9972 mL | |
15 mM | 0.1599 mL | 0.7996 mL | 1.5993 mL | 3.9981 mL | |
20 mM | 0.1199 mL | 0.5997 mL | 1.1994 mL | 2.9986 mL | |
25 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3989 mL | |
30 mM | 0.0800 mL | 0.3998 mL | 0.7996 mL | 1.9991 mL | |
40 mM | 0.0600 mL | 0.2999 mL | 0.5997 mL | 1.4993 mL | |
50 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1994 mL | |
60 mM | 0.0400 mL | 0.1999 mL | 0.3998 mL | 0.9995 mL | |
80 mM | 0.0300 mL | 0.1499 mL | 0.2999 mL | 0.7497 mL | |
100 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL |
Duvelisib (R enantiomer) Related Classifications
- PI3K/Akt/mTOR
- PI3K