ETV6 Antibody - N-terminal region : FITC
Référence P100806_P050-FITC
Conditionnement : 100ul
Marque : Aviva Systems Biology
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ETV6 Antibody - N-terminal region (P100806_P050)
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| Datasheets/Manuals | Printable datasheet for anti-ETV6 (P100806_P050) antibody |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ETV6 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: WAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHIL |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-ETV6 (P100806_P050) antibody is Catalog # AAP31148 (Previous Catalog # AAPP01887) |
| Sample Type Confirmation | ETV6 is supported by BioGPS gene expression data to be expressed in 721_B |
| Reference | Rubnitz,J.E., (2008) J. Clin. Oncol. 26 (13), 2186-2191 |
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| Gene Symbol | ETV6 |
| Gene Full Name | Ets variant 6 |
| Alias Symbols | TEL, THC5, TEL/ABL |
| NCBI Gene Id | 2120 |
| Protein Name | Transcription factor ETV6 |
| Description of Target | ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. it contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Uniprot ID | P41212 |
| Protein Accession # | NP_001978 |
| Nucleotide Accession # | NM_001987 |
| Protein Size (# AA) | 452 |
| Molecular Weight | 53kDa |
| Protein Interactions | AP1M1; WDYHV1; UBC; SUMO1; NEDD8; ETV6; SUMO2; PIN1; HDAC6; SOX2; TRAF3; SOCS3; SOCS1; PDGFRB; ELAVL1; UBE2I; NCOR1; SIN3A; HDAC3; L3MBTL1; SMURF1; HDAC9; KAT5; FLI1; IRF8; SKP1; FBXL6; GAB2; GRB2; CRKL; ACTA1; |
