Fc Fusion Recombinant Protein (Human)
Référence OPED00035
Conditionnement : 50ug
Marque : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for Fc Fusion Recombinant Protein (Human) (OPED00035) (OPED00035) |
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| Predicted Species Reactivity | Human |
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| Product Format | Lyophilized. Contains PBS. |
| Host | HEK 293 cells |
| Additional Information | Thy-1 is a glycosyl phosphatidylinositol (GPI)- anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in T-lymphocytes and cells of the neuronal system. Thy-1 is involved in cell adhesion, and the presence of a RLD motifs, which is recognized by intengrins, strengthen the hypothesis that the Thy-1:integrin interaction is responsible for cell attachment. In astrocytes, binding of Thy-1 to beta 3-integrin triggers tyrosine phosphorylation of focal adhesion proteins. |
| Reconstitution and Storage | Reconstitute with 50 ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. Store at -20C |
| Purification | Purified by multi-step chromatography. |
| Purity | >90% (SDS-PAGE) |
| Application Info | Control compound for Fc Tagged Proteins, ELISA, Flow Cytometry, Functional Application (serves as a negative control in functional assays of TNF-superfamily members). |
| Reference | Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis: M. Filková, et al.; Cytokine 73, 36 (2015), Application(s): Cell Culture: IHC, IF used to analyze IL-35 in PBMCs, Abstract; Lymphotoxin-mediated regulation of gammadelta cell differentiation by alpha beta T cell progenitors: B. Silva-Santos, et al.; Science 307, 925 (2005), Abstract; The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment: T. Keiper, et al.; FASEB J. 19, 2078 (2005), Abstract; Full Text General Literature References Signaling triggered by Thy-1 interaction with beta 3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function: A.M. Avalos, et al.; Biol. Res. 35, 231 (2002), Abstract; Thy-1 binds to integrin beta (3) on astrocytes and triggers formation of focal contact sites: L. Leyton, et al.; Curr. Biol. 11, 1028 (2001), Abstract; |
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| Gene Symbol | FC FUSION |
| Protein Name | Fc Fusion |
| Protein Accession # | NP_000868.1 |
| Nucleotide Accession # | NM_000877.3 |
| Protein Size (# AA) | Recombinant |
| Molecular Weight | 53 kDa |