Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.||Synonyms: |Carbamohydroxamic acid; N-Carbamoylhydroxylamine; N-Hydroxyurea; Biosupressin; Carbamohydroxamic Acid; Carbamoyl Oxime; Cytodrox; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxycarbamide; Hydroxycarbamine; N-(Aminocarbonyl)hydroxylamine; Hydroxylurea; Hydura; Hydurea; Litaler; Litalir; N-Carbamoylhydroxylamine; NCI C04831; NSC 32065; Oxyurea; SK 22591; SQ 1089||CAS Number: |127-07-1||Molecular Formula: |CH4N2O2||Molecular Weight: |76.06||Appearance: |White to off-white crystalline powder||Purity: |97%-103%||Solubility: |Soluble in water, practically insoluble in alcohol, soluble in hot alcohol.||Identification (IR): |Passes USP||Loss on Drying:|≤0.5%||Urea: |≤0.5%||Heavy Metals (Pb): |≤0.002%||Melting Point:|138-145°C||Related Substances: |≤0.2%||Chloride: |≤0.005%||Storage and Stability:|May be stored at 4°C. Stable for 12 months after receipt.