KCNN2 antibody - C-terminal region
Référence ARP35094_T100
Conditionnement : 100ul
Marque : Aviva Systems Biology
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KCNN2 Antibody - C-terminal region (ARP35094_T100)
| Datasheets/Manuals | Printable datasheet for anti-KCNN2 (ARP35094_T100) antibody |
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| Publications | Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimerâ, 8341-53 (2012). 22699914 |
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| Tested Species Reactivity | Human, Rat, Monkey |
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish, Monkey |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC, WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN2 |
| Purification | Protein A purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 100%; Zebrafish: 93% |
| Peptide Sequence | Synthetic peptide located within the following region: IDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDM |
| Concentration | 1.0 mg/ml |
| Blocking Peptide | For anti-KCNN2 (ARP35094_T100) antibody is Catalog # AAP35094 (Previous Catalog # AAPP06325) |
| Reference | Feranchak,A.P., et al., (2004) Gastroenterology 127 (3), 903-913 |
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| Gene Symbol | KCNN2 |
| Gene Full Name | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
| Alias Symbols | SK2, hSK2, SKCA2, KCa2.2, SKCa 2 |
| NCBI Gene Id | 3781 |
| Protein Name | Small conductance calcium-activated potassium channel protein 2 |
| Description of Target | Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes. |
| Uniprot ID | Q9H2S1 |
| Protein Accession # | NP_067627 |
| Nucleotide Accession # | NM_021614 |
| Protein Size (# AA) | 579 |
| Molecular Weight | 64kDa |
| Protein Interactions | SRPK2; SRPK1; UBC; ACTN2; KCNN2; CALM1; |
