Application
| WB, ICC |
|---|---|
| Primary Accession | O95278 |
| Other Accession | NP_001018051.1 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human Laforin Monoclonal IgG1 |
| Target/Specificity | Detects ~40kDa. |
| Other Names | EPM2 Antibody, Epilepsy progressive myoclonus type 2 Lafora disease (laforin) Antibody, Epilepsy progressive myoclonus type 2A Lafora disease (laforin) Antibody, EPM2 Antibody, Epm2a Antibody, Lafora PTPase Antibody, LAFPTPase Antibody, LD Antibody, LDE Antibody, MELF Antibody |
| Clone Names | S84-37 |
| Immunogen | Fusion protein amino acids 1-331 (full-length) of human Laforin. Rat: 90% identity (296/327 amino acids identical). Mouse: 89% identity (295/327 amino acids identical) |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-466 was sufficient for detection of Laforin in 20 µg of human brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Endoplasmic Reticulum |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@clinisciences.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Laforin, also known as Lafora PTPase, is a dual specificity protein phosphatase. Laforin is involved in the control of glycogen metabolism, specifically in preventing the formation of poorly branched glycogen molecules (polyglucosans). Laforin forms a complex with NHLRC1/malin and HSP70 that suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Laforin is expressed in heart, skeletal muscle, kidney, pancreas and brain. Defective Laforin is linked to progressive myoclonic epilepsy type 2 (EPM2).