CD8 Unconjugated
Catalog #
Size
Lymphocyte-gated PBMCs stained with unconjugated CD8 followed by goat anti-mouse IgG Alexa Fluor 488 (RED); Lymphocyte-gated PBMCs stained with only goat anti-mouse IgG Alexa Fluor 488 (BLUE).
| Conjugation | Unconjugated |
|---|---|
| Antigen | CD8 |
| Clone | OKT8 |
| Isotype | IgG2a, k |
| Applications | FC |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Immunogen | Human peripheral blood T lymphocytes |
| Format | 0.09% sodium azide, PBS pH 7.2 |
| Storage | 2-8°C |
| Status | RUO |
Description:
CD8 is a 32-34kDatype I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α forms either a homodimer (2 alpha chains) or a heterodimer with CD8β and is expressed on the surface of cytotoxic T cells, NK cells, cortical thymocytes, and dendritic cells. CD8 functions as a co-receptor for T cell receptor and specifically binds to class I MHC for antigen recognition and T cell activation. The OKT8 specifically binds the alpha chain of human CD8.
CD8 is a 32-34kDatype I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α forms either a homodimer (2 alpha chains) or a heterodimer with CD8β and is expressed on the surface of cytotoxic T cells, NK cells, cortical thymocytes, and dendritic cells. CD8 functions as a co-receptor for T cell receptor and specifically binds to class I MHC for antigen recognition and T cell activation. The OKT8 specifically binds the alpha chain of human CD8.