c-Kit is a 145 kDa transmembrane receptor-type protein tyrosine kinase encoded by the c-Kit proto-oncogene and is the receptor for stem cell factor (SCF). c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. The amino acid sequence of chicken c-kit shows 63% identity to mouse c-Kit and exhibits similar expression patterns in RNA blot analysis suggesting similar biological roles.
Immunogen
Sp/chkit4A4 cells (Sp2/0 cells transfected with chicken c-Kit cDNA)
Conjugate
PE (R-phycoerythrin)
Buffer Formulation
Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer
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6. Schulte CE, von Lindern M, Steinlein P, Beug H, Wiedemann LM. MLL-ENL cooperates with SCF to transform primary avian multipotent cells. EMBO J. 2002;21:4297-306. (FC)
7. Trefil P, Bakst MR, Yan H, Hejnar J, Kalina J, Mucksová J. Restoration of spermatogenesis after transplantation of c-Kit positive testicular cells in the fowl. Theriogenology. 2010;74:1670-6. (FC)