Mouse Anti-Human CD61-UNLB
Référence 9470-01
Conditionnement : 0.1mg
Marque : Southern Biotech
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| Clone | PM6/13 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | Mouse IgG1-UNLB (15H6) |
| Specificity | Human CD61 |
| Alternative Names | Integrin β3, GPIIIa |
| Description | CD61 is the integrin β3 subunit, a 110 kDa transmembrane glycoprotein expressed on platelets, megakaryocytes, and endothelial cells. Integrin β3 associates with gpIIb (CD41) to form the CD41/CD61 complex that mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the αVβ3 vitronectin receptor. |
| Immunogen | Human platelet plasma membrane |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 2,5-7 Immunocytochemistry – Reported in literature 2 Immunoprecipitation – Reported in literature 1 Western Blot-Non-Reducing – Reported in literature 1 Blocking – Reported in literature 1,3,4 Adhesion – Reported in literature 4 ELISA – Reported in literature 3 |
| RRID Number | AB_2796812 |
| Gene ID | 3690 (Human) |
| Gene ID Symbol | ITGB3 (Human) |
| Gene ID Aliases | BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT |
| UniProt ID | P05106 (Human |
| UniProt Name | ITB3_HUMAN (Human) |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Patel Y, Rahman S, Siddiqua A, Wilkinson JM, Kakkar VV, Authi KS. Functional characterization of PM6/13, a β3-specific (GPIIIa/CD61) monoclonal antibody that shows preferential inhibition of fibrinogen binding over fibronectin binding to activated human platelets. Thromb Haemost. 1998;79:177-85. (Immunogen, IP, WB-NR, Block)
- 2. Wilkinson JM, Sankar AA, Currie MJ. The expression of adhesion receptors and cytoskeletal proteins in the megakaryoblastic cell line CHRF-288-11. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1210-13. (FC, ICC)
- 3. Komiya E, Sato H, Watanabe N, Ise M, Higashi S, Miyagi Y, et al. Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3. Cancer Med. 2014;3:537-49. (ELISA, Block)
- 4. Gu Y, Nilsson K, Eng H, Ekblom M. Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma. Br J Haematol. 2000;109:305-13. (Block, Adhesion)
- 5. Hapke S, Kessler H, de Prada NA, Benge A, Schmitt M, Lengyel E. Integrin αvβ3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells. J Biol Chem. 2001;276:26340-8. (FC)
- 6. Lester EA, Babensee JE. Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells. J Biomed Mater Res A. 2003;64:397-410. (FC)
- 7. Rose SL, Babensee JE. Procoagulant phenotype of endothelial cells after coculture with biomaterial-treated blood cells. J Biomed Mater Res A. 2005;72:269-78. (FC)