Polymyxin B nonapeptide (TFA) [2220175-42-6]
Référence HY-106783A-50mg
Conditionnement : 50mg
Marque : MedChemExpress
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
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Polymyxin B nonapeptide TFA Chemical Structure
CAS No. : 2220175-42-6
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Polymyxin B nonapeptide TFA:
- Polymyxin B nonapeptide In-stock
Description |
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3]. |
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In Vitro |
Polymyxin B nonapeptide TFA (2-32 μg/mL, 24 h) has a synergistic effect with Azithromycin (HY-17506)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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In Vivo |
Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Masse moléculaire |
1533.25 |
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Formule |
C43H74N14O11.5C2HF3O2 |
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CAS No. |
2220175-42-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]1(20)[C@H](O)C)=O)CCN)=O)CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@H](CCNC1=O)NC([C@H](CCN)NC([C@@H](N)[C@H](O)C)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.FC(F)(F)C(O)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
DMSO : 100 mg/mL (65.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 50 mg/mL (32.61 mM; ultrasonic and warming and heat to 60°C) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 0.6522 mL | 3.2610 mL | 6.5221 mL | 16.3052 mL |
5 mM | 0.1304 mL | 0.6522 mL | 1.3044 mL | 3.2610 mL | |
10 mM | 0.0652 mL | 0.3261 mL | 0.6522 mL | 1.6305 mL | |
15 mM | 0.0435 mL | 0.2174 mL | 0.4348 mL | 1.0870 mL | |
20 mM | 0.0326 mL | 0.1631 mL | 0.3261 mL | 0.8153 mL | |
25 mM | 0.0261 mL | 0.1304 mL | 0.2609 mL | 0.6522 mL | |
30 mM | 0.0217 mL | 0.1087 mL | 0.2174 mL | 0.5435 mL | |
DMSO | 40 mM | 0.0163 mL | 0.0815 mL | 0.1631 mL | 0.4076 mL |
50 mM | 0.0130 mL | 0.0652 mL | 0.1304 mL | 0.3261 mL | |
60 mM | 0.0109 mL | 0.0544 mL | 0.1087 mL | 0.2718 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Polymyxin B nonapeptide TFA Related Classifications
- Anti-infection
- Bacterial Antibiotic