K1007-1ml | Protease Inhibitor Cocktail(EDTA-Free,100X in DMSO) Clinisciences

Product Citation

1. Xiaoyan Pan, et al. "Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A." Front Cell Dev Biol. 2024 Feb 19:12:1338828. PMID: 38440074
2. Xiaojing Zhang, et al. "The effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury." Lipids Health Dis. 2024 Mar 2;23(1):68. PMID: 38431645
3. Yongyou Zhang, et al. "METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer." Redox Biol. 2024 May:71:103087. PMID: 38377789
4. Su Guo, et al. "Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior." Nucleic Acids Res. 2024 Feb 15:gkae093. PMID: 38366571
5. Qing Zhong, et al. "Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion." Cell Rep. 2024 Feb 27;43(2):113760. PMID: 38340317
6. Qiu-Yue Lin, et al. "Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation." Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167048. PMID: 38296117
7. Bin He, Jiangxue Cai, et al. "Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome." Research Square. 12 May, 2024.
8. Wenzhe Zhang, Rongrong Zhang, et al. "NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance." Cell Rep. 2023 Dec 6;42(12):113531. PMID: 38060382
9. Yue Qin, Xiao-Yong Zhang, et al. "Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms inShank1P1812L-knock-in mice." Transl Psychiatry. 2023 Oct 25;13(1):329. PMID: 37880287
10. Genhong Li, Jingwei Yao, et al. "Simvastatin Preferentially TargetsFLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways." Drugs R D. 2023 Dec;23(4):439-451. PMID: 37847357
11. Chenlu Zhu, Xiao Ren, et al. "Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5× FAD mice." Neural Regen Res. 2024 Apr;19(4):863-871. PMID: 37843222
12. Anat Bahat, Elad Itzhaki, et al. "Lowering mutant huntingtin by small molecules relieves Huntington's disease symptoms and progression." bioRxiv. November 21, 2023.
13. Xuan Gu, Kailing Li, et al. "Aspartyl-tRNA synthetase 2 orchestrates iron-sulfur metabolism in hematopoietic stem cells via fine-tuning alternative RNA splicing." Cell Rep. 2023 Oct 31;42(10):113264. PMID: 37838946
14. Wei-Zhang S, Cui B, et al. "Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration." Iscience, 2023. PMID: 37810255
15. Guo H, Peng X, et al. "Promoting Stem Cell Mechanosensing and Osteogenesis by Hybrid Soft Fibers." ACS Applied Materials & Interfaces, 2023. PMID: 37788009
16. Ling Yuan, Yaoyao Han, et al. "Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex." Nat Commun. 2023 Sep 28;14(1):6071. PMID: 37770519
17. Zhang F, Zhu T, et al. "TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer." Human Cell, 2023: 1-16. PMID: 37709991
18. Boyd R A, Majumder S, et al. "The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation." Cell Reports, 2023, 42(9). PMID: 37689067
19. Mousam Roy, Rachel C Fleisher, et al. "Reduced ADP off-rate by the yeast CCT2 double mutation T394P/R510H which causes Leber congenital amaurosis in humans." Commun Biol. 2023 Aug 29;6(1):888. PMID: 37644231
20. Anthony J Domma, Felicia D Goodrum, et al. "Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins." J Virol. 2023 Oct 31;97(10):e0056323. PMID: 37754763
21. Ma L, Zhang L, et al. "Pharmacological inhibition of protein S-palmitoylation suppresses osteoclastogenesis and ameliorates ovariectomy-induced bone loss." Journal of Orthopaedic Translation, 2023, 42: 1-14. PMID: 37521493
22. Qinrong Ping, Wang C, et al. "TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells." Journal of Translational Medicine, 2023, 21(1): 1-19. PMID: 37461061
23. Jun Zheng, Zhihe Cao, et al. "Ubiquitin Ligase MARCH5 Regulates the Formation of Mitochondria Derived Pre-peroxisomes." bioRxiv. October 26, 2023.
24. Yuan-Li Ai, Wei-Jia Wang, et al. "Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P." Cell Res. 2023 Jul 17. PMID: 37460805
25. Debao Fang, Hao Hu, et al. "MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis." Adv Sci (Weinh). 2023 Jul 12;e2303336. PMID: 37438558
26. Pengyu Geng, Jinhui Zhao, et al. "Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer." Int. J. Mol. Sci. 2023, 24, 17046.
27. Huang J, Chen P, et al. "Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging." Advanced Science, 2023: 2301538. PMID: 37401155
28. Zhao B, Qiao H, et al. "HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway." Virol Sin. 2023 Oct;38(5):680-689. PMID: 37331658
29. Tian Y, Wan N, et al. "Chemoproteomic mapping of the glycolytic targetome in cancer cells." Nature Chemical Biology, 2023: 1-12. PMID: 37322158
30. Xuan L N, Hu Z X, et al. "Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO‐1 pathway." CNS Neuroscience & Therapeutics, 2023. PMID: 37269088
31. Kelli L. Sylvers-Davie, Kaleb C. Bierstedt, et al. "Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins." bioRxiv. August 31, 2023.
32. Hong-Wei Zhang, Kun Huang, et al. "A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex." Nat Commun. 2023 May 30;14(1):3118. PMID: 37253723
33. Yun Chen, Zihao Ou, et al. "Extracellular vesicles derived from Akkermansia muciniphilapromote placentation and mitigate preeclampsia in a mouse model." J Extracell Vesicles. 2023 May;12(5):e12328. PMID: 37165987
34. Domma A J, Henderson L A, et al. "Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins." bioRxiv. 2023 Apr 17:2023.04.17.537203. PMID: 37131605
35. Xiaochun X, Ma G, et al. "Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5× FAD mice." Nature Aging, 2023, 3(2): 202-212. PMID: 37118112
36. Shu X, Shi Y, et al. "Transcription tuned by S-nitrosylation underlies a mechanism for Staphylococcus aureus to circumvent vancomycin killing." Nature communications, 2023, 14(1): 2318. PMID: 37085493
37. Ji X, Gao J, et al. "Fear-of-intimacy-mediated zinc transport is required for Drosophila fat body endoreplication." BMC biology, 2023, 21(1): 1-18. PMID: 37069617
38. Qin Z, Bo Xie, et al. "Over-expression of RRM2 predicts adverse prognosis correlated with immune infiltrates: A potential biomarker for hepatocellular carcinoma." Frontiers in Oncology, 2023, 13: 1144269. PMID: 37056349
39. Geng J, Kang Z, et al. "Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility." Research, 2023, 6: 0054. PMID: 37040508
40. Xiaojie Cai, Maoying Han, et al. "Tenascin C+papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis." Nat Commun. 2023 Apr 10;14(1):2004. PMID: 37037861
41. Andrews J C, Mok J W, et al. "De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features." Genetics in Medicine, 2023, 25(6): 100833. PMID: 37013900
42. Yoon Jung Kim, Michael Lee Jr, et al. "Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions." Sci Adv. 2023 Mar 31;9(13):eadg1123. PMID: 37000871
43. Lv J, Wu W, et al. "Kinase Inhibitor VvBKI1 Interacts with Ascorbate Peroxidase VvAPX1 Promoting Plant Resistance to Oomycetes." International Journal of Molecular Sciences, 2023, 24(6): 5106. PMID: 36982179
44. Cao M, Zou X, et al. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis." Nature Communications, 2023, 14(1): 1687. PMID: 36973243
45. Qiuhong Xiong, Huimin Sun, et al. "WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism." Free Radic Biol Med. 2023 May 20:201:89-97. PMID: 36940732
46. Xu Yang, Tingyu Huang, et al. "Deoxynivalenol induces testicular ferroptosis by regulating the Nrf2/System Xc−/GPX4 axis." Food Chem Toxicol. 2023 May:175:113730. PMID: 36925038
47. Cui Z, Xu Y, et al. "NAT10 promotes osteogenic differentiation of periodontal ligament stem cells by regulating VEGFA-mediated PI3K/AKT signaling pathway through ac4C modification." Odontology, 2023: 1-13. PMID: 36879181
48. Haibo H, Kang Y, et al. "Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish." Plos Biology, 2023, 21(3): e3002008. PMID: 36862758
49. Yun-Long Zhang, Jie Bai, et al. "CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization." J Adv Res. 2023 Feb 21;S2090-1232(23)00061-9. PMID: 36822392
50. Zhang W, Li X, et al. "SOCS3 deficiency-dependent autophagy repression promote the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway." J Leukoc Biol 2023 Feb 20 PMID: 36808484
51. Zhang Q, Luo S, et al. "Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma." Epigenetics, 2023, 18(1): 2175168. PMID: 36734243
52. Yu M, Wang W, et al. "Hydrogen sulfide protects retinal pigment epithelium cells against ferroptosis through the AMPK-and p62-dependent non-canonical NRF2-KEAP1 pathway." Experimental Cell Research, 2023, 422(1): 113436. PMID: 36435220
53. Sun Q, Pei F, et al. "Curved Nanofiber Network Induces Cellular Bridge Formation to Promote Stem Cell Mechanotransduction." Advanced Science, 2023, 10(3): 2204479. PMID: 36382560
54. Chen Y, Zuo X, et al. "Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer." Int J Biol Sci 2023;19(2) PMID: 36632452
55. Yuting Li, Ziqiong Yang, et al. "Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity." iScience. 2022 Oct 6;25(11):105293. PMID: 36300005
56. Jiexin Zhang, Caiwen Ou, et al. "Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota." Ecotoxicol Environ Saf. 2022 Oct 1;244:114057. PMID: 36084504
57. Yao J, Tang S, et al. "Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma." Autophagy, 2023, 19(4): 1221-1238. PMID: 36048765
58. Wei Y, Zhang D, et al. "PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α." Genes & Diseases, 15 July 2023.
59. Haiping Hao, Yang Tian, et al. "Chemoproteomic Mapping of Glycolytic Targetome in Cancer Cells." Research Square. 05 Oct, 2022.
60. Yang Liu, Libo He, et al. "Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway." iScience. 2022 Jun 6;25(7):104533. PMID: 35784791
61. Rachel Shvartsur, Galila Agam, et al. "Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats." Pharmaceutics. 2022 Apr 20;14(5):901. PMID: 35631487
62. Xiong Gao, Ranhua Zeng, et al. "Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies." Food Chem X. 2022 Jan 15:13:100211. PMID: 35498979
63. Romano Strobelt, Julia Adler, et al. "Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism." Sci Rep. 2022 Apr 6;12(1):5758. PMID: 35388061
64. Xi Zhang, Cang Wu, et al. "Cryo-EM structures reveal distinct apo conformations of sortilin-related receptor SORLA." Biochem Biophys Res Commun. 2022 Apr 16;600:75-79. PMID: 35196630
65. Baicun Li, Jiangang Huang, et al. "Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of Hepatocellular Carcinoma." Bioorg Chem. 2022 Apr;121:105651. PMID: 35182885
66. Yongchao Liu, Yu Cong, et al. "Themis is indispensable for IL-2 and IL-15 signaling in T cells." Sci Signal. 2022 Feb 15;15(721):eabi9983. PMID: 35167340
67. Ruikun Wang, Jingru Chen, et al. "CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model." J Immunother Cancer. 2022 Jan;10(1):e003809. PMID: 35086948
68. Qianqian Yin, Libo Sun, et al. "Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication." J Invest Dermatol. 2022 Jan 12;S0022-202X(22)00007-0. PMID: 35032503
69. Adam Haines, Jordan Wesolowski, et al. "Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection." mBio. 2021 Dec 21;12(6):e0239721. PMID: 34903051
70. Xiaoxu Gao, Xiaofei Shen, et al. "Sesquiterpene Lactones fromSigesbeckia glabrescensPossessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β." J Nat Prod. 2021 Nov 26;84(11):2808-2821. PMID: 34726063
71. Xiao Cheng, Ye Liu, et al. "Cantharidin-Loaded Biomimetic MOF Nanoparticles Cascade To Enhance Fenton Reaction Based On Amplified Photothermal Therapy." Biomater Sci. 2021 Nov 23;9(23):7862-7875. PMID: 34676840
72. Jinzhi Tong, Jian Fang, et al. "Pentagalloylglucose Reduces AGE-induced Inflammation by Activating Nrf2/HO-1 and Inhibiting the JAK2/STAT3 Pathway in Mesangial Cells." J Pharmacol Sci. 2021 Dec;147(4):305-314. PMID: 34663512
73. Qing Gao, Xuhong Chang, et al. "LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway‐mediated autophagy." Environ Toxicol. 2022 Jan;37(1):79-91. PMID: 34608745
74. Yanli Liu, Linlong Ma, et al. "Investigation of cell wall proteins of C. sinensis leaves by combining cell wall proteomics and N-glycoproteomics." BMC Plant Biol. 2021 Aug 20;21(1):384. PMID: 34416854
75. Yi Wu, Zhong Zhang, et al. "Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro." Drug Des Devel Ther. 2021 Jul 1;15:2857-2868. PMID: 34234416
76. Xu Z, Hu H, et al. "The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc." Int J Biochem Cell Biol. 2021 Aug;137:106023. PMID: 34102342
77. Lijun Shang, Haitao Yu, et al. "Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota." Biomed Pharmacother. 2021 Apr 2;139:111127. PMID: 33819810
78. Haibing Zhan, Xuhong Chang, et al. "LncRNA MEG3 mediates nickel oxide nanoparticles-induced pulmonary fibrosis via suppressing TGF-β1 expression and epithelial-mesenchymal transition process." Environ Toxicol. 2021 Jun;36(6):1099-1110. PMID: 33547861
79. Xin Zong, Hong Wang, et al. "Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signaling axis." RNA Biol. 2021 Apr;18(4):576-586. PMID: 32914682
80. Shamriz O, Simon AJ, et al. "Exogenous interleukin-2 can rescue in-vitro T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation. Clin Exp Immunol." 2020;200(3):215-227. PMID: 32201938
81. Gao X, Li X, et al. "Preparation, physicochemical characterization, and anti-proliferation of selenium nanoparticles stabilized by Polyporus umbellatus polysaccharide." Int J Biol Macromol. 2020;S0141-8130 (20)30457-8. PMID: 32087224
82. Cap KC, Jung YJ, et al. "Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβconcentrations." Redox Biol. 2020 Jan 31:101446. PMID: 32046944
83. Lu K, Hou W, et al. "Biological evaluation and chemoproteomics reveal potential antibacterial targets of a cajaninstilbene-acid analogue." Eur J Med Chem. 2020 Feb 15;188:112026. PMID: 31918072
84. Wang J, Luo J, et al. "Increased intracellular Cl(-) concentration by activating FAK promotes airway epithelial BEAS-2B cells proliferation and wound healing." Arch Biochem Biophys. 2019 Dec 12:108225. PMID: 31838119
85. Chen Y, Li H, et al. "Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway." Toxicol Appl Pharmacol. 2019 Dec 3:114848. PMID: 31809756
86. Zheng SC, Chang XJ, et al. "A novel RING finger protein CqRNF152-like with self-ubiquitination activity inhibits white spot syndrome virus infection in a crustacean Cherax quadricarinatus." Fish Shellfish Immunol. 2019 Oct 7. pii: S1050-4648(19)30971-4. PMID: 31600596
87. Reuven N, Adler J, et al. "Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing." Biomolecules. 2019 Oct 8;9(10). PMID: 31597252
88. Zhaohui Wang, Yi Ma, et al. "CXCR4‐Enriched Nano‐Trap Targeting CXCL12 in Lung for Early Prevention and Enhanced Photodynamic Therapy of Breast Cancer Metastasis." Advanced Functional Materials. 06 September 2019.
89. Zhuoyang Fan, Jing He, et al. "Silencing of HMOX1 enhances apoptosis caused by arsenic trioxide in HCC." Int J Clin Exp Med 2019;12(8):9858-9870
90. Cheng L, Li J, et al. "N-linoleyltyrosine protects against transient cerebral ischemia in gerbil via CB2 receptor involvement in PI3K/Akt signaling pathway. " Biol Pharm Bull. 2019 Sep 3. PMID: 31484847
91. Christopher C. Nguyen, Anthony J. Domma, et al. "ER reorganization and intracellular retention of CD58 are functionally independent properties of the human cytomegalovirus ER resident glycoprotein UL148." bioRxiv. 2019 August 27.
92. Sun L, Büeler H. "Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1." Biochem Biophys Res Commun. 2019 Jul 27. pii: S0006-291X(19)31401-9. PMID: 31362890
93. Li T, Wei Z, et al. "Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway." Molecules. 2019 Jul 17;24(14). pii: E2596. PMID: 31319488
94. Na-Na He, Ting Wang, et al. "Yiqi Fusheng Decoction reverses cisplatin resistance in colorectal cancer by down-regulating HIF-1α and p-ERK1/2."Drug Combination Therapy. 2019, Vol. 1 Issue (1): 31-39
95. Losier TT, Akuma M,et al. "AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles." Cell Rep. 2019 Feb 19;26(8):2150-2165.e5. PMID: 30784596
96. Li SM, Zhao YQ, et al. "Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2." Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1203-1213. PMID: 30779090
97. Ma F, Chang X, et al. "Streptococcus Suis Serotype 2 Stimulates Neutrophil Extracellular Traps Formation via Activation of p38 MAPK and ERK1/2." Front Immunol. 2018 Dec 7;9:2854. PMID: 30581435
98. Liu ZB, Tang C, et al. "Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway." Cancer Biomark. 2018;23(4):603-613. PMID: 30452404
99. Lu XY, Zhou FH, et al. "Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin." Nat Prod Bioprospect. 2018 Dec;8(6):441-451. PMID: 30387083
100. Lu Xianyuan,Zou Wei, et al. "Anti-renal fibrosis effect of asperulosidic acid via TGF-β1/smad2/smad3 and NF-κB signaling pathways in a rat model of unilateral ureteral obstruction." Phytomedicine Available online 5 September 2018.
101. Michele Renae Plewes. "The Effects of in Vitro Fish Oil and Dietary Fish Meal Supplementation on Microdomains Within Bovine Luteal Cells." University of Northern Colorado.2018.
102. Shi G, Zhang H, et al. "Epigenetic silencing of sonic hedgehog elicits antitumor immune response and suppresses tumor growth by inhibiting the hedgehog signaling pathway in metastatic spine tumors in Sprague-Dawley rats." J Cell Biochem. 2018 Nov;119(11):9591-9603. PMID: 30191602
103. Gao X, Bao S, et al."Fructose-1,6-bisphosphate aldolase of Mycoplasma bovis is a plasminogen-binding adhesin." Microb Pathog. 2018 Aug 22;124:230-237. PMID: 30142464
104. M.R. Plewes, P.D. Burns. "Effect of fish oil on agonist-induced receptor internalization of the prostaglandin F 2α receptor and cell signaling in bovine luteal cells in vitro." Domestic Animal Endocrinology. 2017 December 12.
105. Rana PS, Mudrak NJ, et al. "Phase separation in necrotic cells." Biochem Biophys Res Commun. 2017 Oct 21;492(3):300-303. PMID: 28859980
106. Sangbin Lim, Hao Liu, et al. "PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α." Cancer Res. 2016 Apr 15;76(8):2231-42. PMID: 27197253

Hide ↑↑

Quality Control

Related Biological Data

Related Biological Data

Protocol

Thaw at room temperature, add at 1:100 (v/v) dilution to solution samples (such as cell lysates or tissue extracts) before assaying.

Applications: WB, Co-IP, pull-down, IF, IHC, kinase assay and etc.

Components and Storage

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2573	AEBSF.HCl	Serine protease inhibitor	Proteases\|Serine Protease	30827-99-7	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
A2574	Aprotinin	Inhibitor of bovine pancreatic trypsin	Proteases\|Serine Protease	9087-70-1
A2575	Bestatin	Aminopeptidase inhibitor	Proteases\|Aminopeptidase	58970-76-6	CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
A2576	E-64	Cysteine protease inhibitor,irreversible	Proteases\|Cathepsin	66701-25-5	CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
A2570	Leupeptin	Inhibitor of serine and cysteine proteases	Proteases\|Serine Protease	103476-89-7	O=C(C(C(22)(22)C(C(22)(22)22)(22)C(22)(22)22)(22)N(22)C(C(22)(22)22)=O)N(22)C(C(N(22)C(C(22)=O)(22)C(22)(22)C(22)(22)C(22)(22)/N=C(N(22)22)/N(22)22)=O)(22)C(22)(22)C(C(22)(22)22)(22)C(22)(22)22
A2571	Pepstatin A	Aspartic protease inhibitor	Proteases\|Other Proteases	26305-03-3	CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O
Stored at -20°C, and stable for at least 12 months.

Description

Endogenous proteins are produced and degraded in a balanced state, so their cellular levels are stable under stable environmental conditions. Crude cell extracts contain a number of endogenous enzymes, such as phosphatases and proteases, which are capable of degrading proteins in the extracts. Protein production is greatly halted and degradation is increased when proteins are extracted from cells and tissues in vitro. The best way to increase the yield of intact proteins is to add inhibitors of those enzymes known to be present.

Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability. The cocktail functions to inhibit proteases that would degrade either non-phosphorylated or phosphorylated protein substrates.

This protease inhibitor cocktail contains individual components, including AEBSF, Aprotinin, Bestatin, E-64, Leupeptin and Pepstatin A with a broad specificity for cysteine, serine, acid proteases, and aminopeptidases. This protease inhibitor cocktail has been optimized and tested for mammalian cells and tissue extracts. This protease inhibitor cocktail is supplied as a ready-to-use solution in DMSO.

Storage

Stored at -20°C, and stable for at least 12 months.

Protease Inhibitor Cocktail(EDTA-Free,100X in DMSO)

Référence K1007-1ml

Contactez votre distributeur local :

Marque : APExBIO Technology

Contactez votre distributeur local :

Product Citation

Quality Control

Related Biological Data

Related Biological Data

Related Biological Data

Related Biological Data

Related Biological Data

Related Biological Data

Related Biological Data

Related Biological Data

Protocol

Components and Storage

Description

Storage

Vous serez peut-être également intéressé par les produits suivants :