Recombinant Human TNF RII (Mammalian, C-6His)
Référence M43957-10ug
Conditionnement : 10ug
Marque : AbMole Bioscience
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Tumor Necrosis Factor Receptor II; TNFRSF1B
Quality Control & Documentation
Biological Activity
Recombinant Human TNF RII belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha function by antagonizing its biological activity.
Recombinant Human Tumor Necrosis Factor Receptor II expressed the target gene encoding Leu23-Asp257 with a 6His tag at the C-terminus.
The ED50 of Recombinant Human TNF RII (C-6His) is 0.212 ug/ml.
Accession: P20333
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 40 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Chemical Information
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
References
[1] Dao Xuan Nguyen, et al. J Exp Med. Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis
[2] M Aringer, et al. Lupus. Increased bioactive TNF in human systemic lupus erythematosus: associations with cell death
[3] C K Edwards 3rd. Ann Rheum Dis. PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases
[4] M Aoki, et al. J Vet Med Sci. Cytotoxicity induced by recombinant human tumor necrosis factor-alpha dependent on the types of its receptors on canine cells
[5] A Gessl, et al. Immunology. Tumour necrosis factor-alpha augments the expression of Fc IgE receptor (Fc epsilon RII/CD23) on human monocytic cell lines and down-regulates interleukin-4-driven Fc epsilon RII expression on monocytes