Sulfaguanidine

Biological Activity

Sulfaguanidine is a sulfonamide used as an anti-infective agent.

Chemical Information

Molecular Weight	214.24
Formula	C7H10N4O2S
CAS Number	57-67-0
Form	Solid
Solubility (25°C)	DMSO 30 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hemat M Dardeer, et al. Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO 2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

[2] Ahmed Ragab, et al. Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

[3] S. Russ Richardson, et al. Glucose 6 Phosphate Dehydrogenase Deficiency

[4] Syed Sibte Asghar Abidi, et al. Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis

[5] C A Hoppert. SULFAGUANIDINE OR SULFA-AMIDINE?