TAZ Polyclonal Antibody, PE-Cy7 Conjugated
Référence bs-12367R-PE-Cy7
Conditionnement : 100ul
Marque : Bioss
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TAZ Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-12367R-PE-Cy7 |
| Product Name | TAZ Polyclonal Antibody, PE-Cy7 Conjugated |
| Applications | WB, FCM |
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | PE-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human TAZ |
| Immunogen Range | 1-100/400 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 25937 |
| Swiss Prot | Q9GZV5 |
| Subcellular location | Cytoplasm, Nucleus, Cell membrane |
| Synonyms | TAZ; WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif; WWTR1 |
| Background | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |