A2517-1g | Tetracycline Hydrochloride [64-75-5] Clinisciences

Background

Tetracycline Hydrochloride is an inhibitor of bacterial ribosomes [1].

Tetracycline Hydrochloride is believed to inhibit translation by binding to the 16S rRNA and inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. However, the exact target site(s) and mechanism(s) of action remain subjects of much debate [1].

Tetracycline Hydrochloride at doses of 0, 10, 25, 50, 75, 150, 225 and 300 µM exhibited increasing antimicrobial effect against resistant strains of Staphylococcus aureus (S. aureus). The statistically evaluated IC50 values of Tetracycline Hydrochloride against S. aureus, cadmium-resistant S. aureus, and lead-resistant S. aureus after first 6 h were 4.8, 3.8, 2.2 µM, respectively [2].

In humans who had minimum Propionibacterium acnes (P. acnes) levels of 10000 colony-forming units per cm² at baseline, Tetracycline Hydrochloride treatment (1000 mg/d, b.i.d., p.o.) over a 6-week period significantly reduced P. acnes on both cheeks and forehead after 3 and 6 weeks, but produced little to no residual effect. At 9 weeks, P. acnes levels in the Tetracycline Hydrochloride group had returned to baseline [3].

References:

[1]. Chukwudi C U. rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines. Antimicrobial Agents and Chemotherapy, 2016, 60(8): 4433-4441.

[2]. Chudobova D, Dostalova S, Blazkova I, et al. Effect of ampicillin, streptomycin, penicillin and tetracycline on metal resistant and non-resistant Staphylococcus aureus. International Journal of Environmental Research and Public Health, 2014, 11(3): 3233-3255.

[3]. Leyden J J, Kaidbey K, Gans E H. The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans. Journal of Dermatological Treatment, 1996, 7: 223-225.

Product Citation

1. Shen X, Zhao Y, et al. "Upregulation of programmed death ligand 1 by liver kinase B1 and its implication in programmed death 1 blockade therapy in non-small cell lung cancer." Life Sci. 2020;256:117923. PMID:32522567

Chemical Properties

Storage	Store at -20°C
M.Wt	480.90
Cas No.	64-75-5
Formula	C₂₂H₂₅ClN₂O₈
Solubility	insoluble in EtOH; ≥12.02 mg/mL in DMSO with gentle warming; ≥57.7 mg/mL in H2O
Chemical Name	(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
SDF	Download SDF
Canonical SMILES	CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Purity = 98.48%

Chemical structure

Tetracycline Hydrochloride [64-75-5]

Référence A2517-1g

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