TFR Recombinant Protein
Référence OPCD07361-200UG
Conditionnement : 200ug
Marque : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for TFR Recombinant Protein (OPCD07361) |
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| Predicted Species Reactivity | Homo sapiens|Human |
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| Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Host | E.coli |
| Conjugation | Unconjugated |
| Application | Ctrl (+), SDS-PAGE, WB |
| Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| :: | Residues: Gly567-Gly744 |
| Reconstitution and Storage | 2°C to 8°C|-80°C |
| Concentration | 200 ug/mL (prior to lyoph) |
| Purity | > 95% |
| Source | E.coli |
| Tag | N-terminal His Tag |
| Gene Symbol | TFRC |
|---|---|
| Gene Full Name | transferrin receptor |
| Alias Symbols | CD71;IMD46;p90;T9;TFR;TFR1;TR;transferrin receptor protein 1;TRFR. |
| NCBI Gene Id | 7037 |
| Protein Name | Transferrin receptor protein 1 |
| Description of Target | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). |
| Uniprot ID | P02786 |
| Protein Accession # | NP_001121620.1 |
| Nucleotide Accession # | NM_001128148.2 |
| Protein Size (# AA) | Gly567~Gly744 |
| Molecular Weight | 29kDa |