(S)-N-Deacetyl Colchicine
Product Code
TRC-D198920
CAS Number
3476-50-4
Product Format
Neat
Molecular Formula
C20 H23 N O5
Molecular Weight
357.40
Product Type
ImpurityPurity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
N-Deacetylcolchicine
CAS Number
3476-50-4
Molecular Formula
C20 H23 N O5
Molecular Weight
357.40
Accurate Mass
357.1576
SMILES
COC1=CC=C2C(=CC1=O)[C@@H](N)CCc3cc(OC)c(OC)c(OC)c23
InChI
InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1
IUPAC
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzopmheptalen-9-one
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Format
Neat
Purity
>95% (HPLC)
Product Description
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Alali, F., et al.: Phytochem. Anal., 19, 385 (2008), Chang, D., et al.: Bioorg. Med. Chem. Lett., 19, 4416 (2009),
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