General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ATP-binding cassette sub-family G member 1 (560-640 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ABCG1 |
| Gene ID: | 9619 |
| Uniprot ID: | ABCG1_HUMAN |
| Immunogen Region: | 560-640 aa |
| Specificity: | ABCG1 Polyclonal Antibody detects endogenous levels of ABCG1 protein. |
| Immunogen: | Synthesized peptide derived from ABCG1 at the amino acid range 560-640 |
Description
| Post Translational Modifications | Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. |
| Function | Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 1Atp-Binding Cassette Transporter 8White Protein Homolog |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-8964058Reactome: R-HSA-9029569 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCell MembranePredominantly Localized In The Intracellular Compartments Mainly Associated With The Endoplasmic Reticulum (Er) And Golgi Membranes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 1 antibodyAnti-Atp-Binding Cassette Transporter 8 antibodyAnti-White Protein Homolog antibodyAnti-ABCG1 antibodyAnti-ABC8 antibodyAnti-WHT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance