General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ABCG4 (270-370) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ABCG4 |
| Gene ID: | 64137 |
| Uniprot ID: | ABCG4_HUMAN |
| Immunogen Region: | 270-370 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-370 of human ABCG4 (NP_071452.2). |
| Immunogen Sequence: | KLYILSQGQCIFKGVVTNLI PYLKGLGLHCPTYHNPADFI IEVASGEYGDLNPMLFRAVQ NGLCAMAEKKSSPEKNEVPA PCPPCPPEVDPIESHTFATS T |
Description
| Tissue Specificity | Expressed specifically in the brain and the eye. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 4 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneEndosome Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 4 antibodyAnti-ABCG4 antibodyAnti-WHITE2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance