General Info
| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-ACAA2 (298-397) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ACAA2 |
| Gene ID: | 10449 |
| Uniprot ID: | THIM_HUMAN |
| Immunogen Region: | 298-397 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 298-397 of human ACAA2 (P42765). |
| Immunogen Sequence: | PAISGALKKAGLSLKDMDLV EVNEAFAPQYLAVERSLDLD ISKTNVNGGAIALGHPLGGS GSRITAHLVHELRRRGGKYA VGSACIGGGQGIAVIIQSTA |
Description
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Ketoacyl-Coa Thiolase - Mitochondrial antibodyAnti-Acetyl-Coa Acetyltransferase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Acyl-Coa Hydrolase - Mitochondrial antibodyAnti-Beta-Ketothiolase antibodyAnti-Mitochondrial 3-Oxoacyl-Coa Thiolase antibodyAnti-T1 antibodyAnti-ACAA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance