Anti-IGHG1 antibody (196-245 aa)

Référence NB-22-3656-50

Conditionnement : 50ug

Marque : Neo Biotech

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  • Immunohistochemistry analysis of IgG1 antibody in paraffin-embedded human lung carcinoma tissue.
  • Western blot analysis of lysate from LOVO cells, using IgG1 antibody.
  • Western blot analysis of colo cells using IgG1 Polyclonal Antibody diluted at 1:500

General Info

Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Immunoglobulin heavy constant gamma 1 (196-245 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Information

Gene Symbol: IGHG1Uniprot ID=IGHG1_HUMAN"
Immunogen Region: 196-245 aa
Specificity: IgG1 Polyclonal Antibody detects endogenous levels of IgG1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human IgG1 at the amino acid range 196-245

Description

Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.
Protein Name Immunoglobulin Heavy Constant Gamma 1
Ig Gamma-1 Chain C Region
Ig Gamma-1 Chain C Region Eu
Ig Gamma-1 Chain C Region Kol
Ig Gamma-1 Chain C Region Nie
Cellular Localisation Isoform 1: Secreted
Isoform 2: Cell Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Immunoglobulin Heavy Constant Gamma 1 antibody
Anti-Ig Gamma-1 Chain C Region antibody
Anti-Ig Gamma-1 Chain C Region Eu antibody
Anti-Ig Gamma-1 Chain C Region Kol antibody
Anti-Ig Gamma-1 Chain C Region Nie antibody
Anti-IGHG1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance