General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-KLB (720-990) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | KLB |
| Gene ID: | 152831 |
| Uniprot ID: | KLOTB_HUMAN |
| Immunogen Region: | 720-990 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1). |
| Immunogen Sequence: | ALAWRLYDRQFRPSQRGAVS LSLHADWAEPANPYADSHWR AAERFLQFEIAWFAEPLFKT GDYPAAMREYIASKHRRGLS SSALPRLTEAERRLLKGTVD FCALNHFTTRFVMHEQLAGS RYDSDRDIQFLQDITRLSSP TRLAVIPWGVRKLLRWVRRN YGDMDIYITASGIDDQALED DRLRKYYLGKYLQEVLKAYL IDKVRIKGYYAFKLAEEKSK PRFGFFTSDFKAKSSIQFY |
Description
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. |
| Protein Name | Beta-KlothoBklBetaklothoKlotho Beta-Like Protein |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1307965Reactome: R-HSA-2219530Reactome: R-HSA-5654228Reactome: R-HSA-5654712Reactome: R-HSA-5654719Reactome: R-HSA-5654720Reactome: R-HSA-5654733Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-Klotho antibodyAnti-Bkl antibodyAnti-Betaklotho antibodyAnti-Klotho Beta-Like Protein antibodyAnti-KLB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance