General Info
| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IHC/IF/IP/WB |
| Reactivity: | Chicken/Human/Monkey/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RIP140 (50-100) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.60 µg/µl |
| Dilution Range: | WB: 1:1, 000DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Nrip1 |
| Gene ID: | 268903 |
| Uniprot ID: | NRIP1_MOUSE |
| Immunogen Region: | 50-100 |
| Specificity: | Recognizes RIP140 at the N terminal region containing the HDAC binding domain. |
| Immunogen: | Synthetic peptide taken within amino acid region 50-100 on mouse receptor interacting protein 140. |
Description
| Tissue Specificity | Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. |
| Post Translational Modifications | Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. Acetylation regulates its nuclear translocation and corepressive activity. |
| Function | Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Protein Name | Nuclear Receptor-Interacting Protein 1Nuclear Factor Rip140Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-MMU-3899300Reactome: -MMU-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor-Interacting Protein 1 antibodyAnti-Nuclear Factor Rip140 antibodyAnti-Receptor-Interacting Protein 140 antibodyAnti-Nrip1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance