General Info
Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human/Mouse/Rat/Cat/Dog/Pig/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-Serotonin receptor 1B/HTR1B (C-Term) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-1-3µg/mlELISA-antibody detection limit dilution 1:128000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Information
Gene Symbol: | HTR1B |
Gene ID: | 3351 |
Uniprot ID: | 5HT1B_HUMAN |
Immunogen Region: | C-Term |
Accession Number: | NP_000854.1 |
Immunogen Sequence: | SNEDFKQAFHK |
Description
Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
Protein Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bS12Serotonin 1d Beta Receptor5-Ht-1d-BetaSerotonin Receptor 1b |
Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1b antibodyAnti-5-Ht-1b antibodyAnti-5-Ht1b antibodyAnti-S12 antibodyAnti-Serotonin 1d Beta Receptor antibodyAnti-5-Ht-1d-Beta antibodyAnti-Serotonin Receptor 1b antibodyAnti-HTR1B antibodyAnti-HTR1DB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance