General Info
| Host: | Goat |
| Applications: | Pep-ELISA/IF |
| Reactivity: | Human/Mouse/Rat/Pig/Rabbit/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-SLC2A4 (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | IF-Immunofluorescence: Strong expression of the protein seen in the membrane and cytoplasm of NIH3T3 cells. 10µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Information
| Gene Symbol: | SLC2A4 |
| Gene ID: | 6517 |
| Uniprot ID: | GLUT4_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001033.1 |
| Immunogen Sequence: | NLEGPARKSLKRLT |
Description
| Post Translational Modifications | Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. |
| Function | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. |
| Protein Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4Glucose Transporter Type 4 - Insulin-ResponsiveGlut-4 |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-189200Reactome: R-HSA-381340 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndomembrane SystemCytoplasmPerinuclear RegionLocalizes Primarily To The Perinuclear RegionUndergoing Continued Recycling To The Plasma Membrane Where It Is Rapidly ReinternalizedThe Dileucine Internalization Motif Is Critical For Intracellular SequestrationInsulin Stimulation Induces Translocation To The Cell Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 antibodyAnti-Glucose Transporter Type 4 - Insulin-Responsive antibodyAnti-Glut-4 antibodyAnti-SLC2A4 antibodyAnti-GLUT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance