Anti-TRIB3 (Tribbles Homolog 3, TRB-3, Neuronal Cell Death-inducible Putative Kinase, SINK, p65-interacting Inhibitor of NF-kappa-B, C20orf97, NIPK, SKIP3, TRB3) Polyclonal Antibody

A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.||Applications:|Suitable for use in Western Blot. Other applications not tested.||Recommended Dilution:|Western Blot: 1-3ug/ml|Optimal dilutions to be determined by the researcher.||Positive Control:|Human liver lysate||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.