Anti-TSG101 antibody (330-390) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150 ICC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	TSG101
Gene ID:	7251
Uniprot ID:	TS101_HUMAN
Immunogen Region:	330-390
Immunogen:	Synthetic peptide taken within amino acid region 330-390 on Tumor susceptibility gene 101 protein.

Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Post Translational Modifications	Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis.the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-ST-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes.
Protein Name	Tumor Susceptibility Gene 101 Protein Escrt-I Complex Subunit Tsg101
Database Links	Reactome: R-HSA-162588 Reactome: R-HSA-174490 Reactome: R-HSA-917729 Reactome: R-HSA-9610379 Reactome: R-HSA-9615710
Cellular Localisation	Cytoplasm Early Endosome Membrane Peripheral Membrane Protein Cytoplasmic Side Late Endosome Membrane Cytoskeleton Microtubule Organizing Center Centrosome Midbody Midbody Ring Nucleus Mainly Cytoplasmic Membrane-Associated When Active And Soluble When Inactive Nuclear Localization Is Cell Cycle-Dependent Interaction With Cep55 Is Required For Localization To The Midbody During Cytokinesis
Alternative Antibody Names	Anti-Tumor Susceptibility Gene 101 Protein antibody Anti-Escrt-I Complex Subunit Tsg101 antibody Anti-TSG101 antibody

Information sourced from Uniprot.org

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