Anti-Vinculin antibody (Clone: FB11)

Clonality:	Monoclonal
Clone ID:	FB11
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS with 1% BSA & 0.1% sodium azide
Concentration:	100 ug/mL
Dilution Range:	IHC-F WB 1:1000 ELISA
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	VCL
Gene ID:	7414
Uniprot ID:	VINC_HUMAN
Immunogen:	Vinculin purified from human smooth muscle

Tissue Specificity	Metavinculin is muscle-specific.
Post Translational Modifications	Phosphorylated.on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques. Acetylated.mainly by myristic acid but also by a small amount of palmitic acid.
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Protein Name	Vinculin Metavinculin Mv
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-445355 Reactome: R-HSA-5674135 Reactome: R-HSA-6798695 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9725370
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Junction Adherens Junction Focal Adhesion Cytoplasm Cytoskeleton Sarcolemma Cell Projection Podosome Recruitment To Cell-Cell Junctions Occurs In A Myosin Ii-Dependent Manner Interaction With Ctnnb1 Is Necessary For Its Localization To The Cell-Cell Junctions
Alternative Antibody Names	Anti-Vinculin antibody Anti-Metavinculin antibody Anti-Mv antibody Anti-VCL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance