General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-VLDLR (833-869) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | VLDLR |
| Gene ID: | 7436 |
| Uniprot ID: | VLDLR_HUMAN |
| Immunogen Region: | 833-869 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 833-869 of human VLDLR (NP_003374.3). |
| Immunogen Sequence: | DNPVYLKTTEEDLSIDIGRH SASVGHTYPAISVVSTD |
Description
| Tissue Specificity | Abundant in heart and skeletal muscle.also ovary and kidney.not in liver. |
| Post Translational Modifications | Ubiquitinated at Lys-839 by MYLIP leading to degradation. Glycosylated. |
| Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone. (Microbial infection) Acts as a receptor for Semliki Forest virus. |
| Protein Name | Very Low-Density Lipoprotein ReceptorVldl ReceptorVldl-R |
| Database Links | Reactome: R-HSA-8866376Reactome: R-HSA-8866427Reactome: R-HSA-8964046 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneClathrin-Coated Pit |
| Alternative Antibody Names | Anti-Very Low-Density Lipoprotein Receptor antibodyAnti-Vldl Receptor antibodyAnti-Vldl-R antibodyAnti-VLDLR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance