BIX01294 hydrochloride [1392399-03-9]

BIX01294 hydrochloride has emerged as a pivotal tool in scientific investigations, particularly in the realm of epigenetics and chromatin biology. Its mechanism of action revolves around the inhibition of histone methyltransferase enzymes, specifically targeting G9a and G9a-like protein (GLP). Through this targeted inhibition, BIX01294 hydrochloride exerts a regulatory influence on histone H3 lysine 9 (H3K9) methylation, a crucial epigenetic mark associated with gene expression regulation and chromatin structure. Research endeavors have harnessed the unique properties of BIX01294 hydrochloride to explore the intricate dynamics of epigenetic modifications and their impact on various cellular processes. Studies utilizing BIX01294 hydrochloride have provided invaluable insights into the role of histone methylation in gene silencing, chromatin remodeling, and cellular differentiation. Moreover, BIX01294 hydrochloride has facilitated investigations into the epigenetic basis of disease states, offering potential avenues for intervention. Its utility extends to elucidating the crosstalk between epigenetic modifications and other regulatory pathways, contributing to a comprehensive understanding of cellular physiology and pathophysiology. By virtue of its specificity and efficacy in inhibiting histone methyltransferases, BIX01294 hydrochloride continues to be a cornerstone in epigenetic research, driving forward our knowledge of chromatin dynamics and epigenetic regulation in health and disease.

References:

1. A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum.  |  Ukaegbu, UE., et al. 2015. PLoS Genet. 11: e1005234. PMID: 25993442
2. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.  |  Green, KM., et al. 2019. J Biol Chem. 294: 18624-18638. PMID: 31649034
3. Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms.  |  Song, H., et al. 2020. Int J Mol Sci. 21: PMID: 32605171
4. A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules.  |  Zorn, KM., et al. 2021. ACS Infect Dis. 7: 406-420. PMID: 33434015
5. High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas.  |  Tatman, PD., et al. 2021. J Clin Med. 10: PMID: 34300316
6. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells.  |  Li, W., et al. 2022. Elife. 11: PMID: 35617485