C3 / C3c antibody (FITC)
Référence GTX73472-1ml
Conditionnement : 1ml
Marque : GeneTex
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Téléphone : +1 850 650 7790
Host | Rabbit |
|---|---|
Clonality | Polyclonal |
Isotype | IgG |
Application | ICC/IF, IHC-P |
Reactivity | Human, Mouse, Rat, Goat, Sheep, Bovine, Cat, Dog, Guinea pig, Pig, Mink |
| Package | 1 ml |
Datasheet File View product citations for antibody GTX73472 on CiteAb
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application | Recommended Dilution |
|---|---|
| ICC/IF | Assay dependent |
| IHC-P | 1:75-1:100 |
| Note : IHC-PAntigen retrieval : Proteinase K 30 min at 37ºC | |
Not tested in other applications.
Calculated MW
187 kDa. ( Note )
Product Note
This antibody reacts with human C3c complement and with the C3c part of C3 and C3b.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. Protect from light.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
C3c Complement isolated from complement-activated human serum.
Purification
Purified IgG
Conjugation
Fluorescein isothiocyanate (FITC) Wavelength
RRID
AB_374934
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
complement C3 , AHUS5 , ARMD9 , ASP , C3a , C3b , CPAMD1 , HEL-S-62p
Cellular Localization
Secreted
Background
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Database
Application Reference
Park SY et al. J Immunol 2008; 181 (9) : 6328-36 Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
Application : ICC/IF
Reactivity : Human
REVIEW
Application Reference
Park SY et al. J Immunol 2008; 181 (9):6328-36 Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
Application : ICC/IF
Reactivity : Human
| SDS | |
|---|---|
| PBS.pdf | |
| Sodium Azide.pdf | |