CA 19-9 Mouse Monoclonal Antibody [Clone ID: 121SLE]
Référence AM33126PU-T
Conditionnement : 20ug
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| Product Data | |
| Clone Name | 121SLE |
|---|---|
| Application | FC, IF, IHC, WB |
| Application | ELISA: Use BSA free Antibody for coating. Western Blot: 0.5-1.0 µg/ml. Flow Cytometry: 0.5-1.0 µg/106 cells. Immunofluorescence: 0.5-1.0 µg/ml. Immunohistochemistry on Formalin-Fixed Paraffin Sections: 0.5-1.0 µg/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Positive Control: Stomach or Colon Carcinoma. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgM |
| Clonality | Monoclonal |
| Immunogen | Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le). |
| Specificity | This 121SLE antibody is specific to CA19-9, which can predict recurrence of disease prior to radiographic treatment. Cellular Localization: Cytoplasmic. |
| Buffer | 10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Predicted Protein Size | > 400 kDa |
| Background | CA19-9, a carbohydrate epitope expressed on a high MW (> 400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. |
| Synonyms | CA19-9, Sialosyl Lewis a, Sialyl Lewis a |
| Reference Data | |
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