Camostat Mesilate [59721-29-8]
Référence B2082-10mg
Conditionnement : 10mg
Marque : APExBIO Technology
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Téléphone : +1 850 650 7790
Camostat Mesilate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
- 1. Ann-Kathrin Reuschl, et al. "Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants." Nat Microbiol. 2024 Feb;9(2):451-463. PMID: 38228858
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 494.52 |
| Cas No. | 59721-29-8 |
| Formula | C20H22N4O5·CH4O3S |
| Solubility | insoluble in EtOH; ≥160.6 mg/mL in DMSO; ≥32.15 mg/mL in H2O |
| Chemical Name | [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid |
| SDF | Download SDF |
| Canonical SMILES | CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
| Cell lines | Rat primary hepatic stellate cells (HSCs) |
| Reaction Conditions | 500 μmol/L camostat mesilate for 7 d incubation |
| Applications | Camostat mesilate (500 μmol/L) inhibited generation of transforming growth factor β (TGF-β) by suppressing plasmin activity and reduced the activity of TGF-β, which blocked in vitro activation of HSCs. |
| Animal experiment:[1] | |
| Animal models | Male Wistar rats |
| Dosage form | 1 ~ 2 mg/g Diet |
| Applications | Camostat mesilate (1 ~ 2 mg/g of diet) markedly attenuated an increase in hepatic plasmin and TGF-β levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum-treated rats. Therefore, camostat mesilate prevented porcine serum-induced rat hepatic fibrosis via a profound reduction in TGF-β generation |
| Note | The technical data provided above is for reference only. |
| References: 1. Okuno M, Akita K, Moriwaki H, et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001, 120(7): 1784-1800. | |