CD14 Mouse Monoclonal Antibody [Clone ID: Tük4]
Référence SM1066LE
Conditionnement : 500ug
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| Product Data | |
| Clone Name | Tük4 |
|---|---|
| Application | ELISA, FC, FN, WB |
| Application | Flow Cytometry: 1/100 - 1/200; use 10 µl of suggested working dilution to label 1x10e6 cells or 100 µl whole blood. ELISA. Western Blot: under reducing conditions. Functional Assays. |
| Reactivity | Bovine, Canine, Feline, Goat, Human, Mink, Monkey, Porcine, Rabbit, Sheep |
| Antibody Host | Mouse |
| Clonality | Monoclonal |
| Specificity | This antibody recognises the CD14 cell surface antigen, expressed strongly by most peripheral blood monocytes and weakly on granulocytes. Clone Tuk4 has been shown to block SDF-induced chemotaxis of U937 cells in a dose-dependent manner. |
| Buffer | PBS State: Low Endotoxin State: Liquid purified IgG |
| Concentration | lot specific |
| Purification | Affinity chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Gene Name | CD14 molecule |
| Database Link | |
| Background | CD14 is a single copy gene encoding 2 protein forms: a 50 to 55 kDa glycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liver derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes. |
| Synonyms | CD14 |
| Note | Endotoxin Level: less than 0.01 EU/µg |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.