CD45 Blocking Peptide

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PTPRC
Gene ID:	5788
Uniprot ID:	PTPRC_HUMAN
Immunogen Region:	1100-1150
Specificity:	This blocking peptide is recommended for use in combination with CD45 antibody, STJ505938
Immunogen:	Synthetic peptide taken within amino acid region 1100-1150 on human Receptor-type tyrosine-protein phosphatase C.

Post Translational Modifications	Heavily N- and O-glycosylated.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Peptide Name	Receptor-Type Tyrosine-Protein Phosphatase C Leukocyte Common Antigen L-Ca T200 Cd Antigen Cd45
Database Links	Reactome: R-HSA-202427 Reactome: R-HSA-416700 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Colocalized With Dpp4 In Membrane Rafts
Alternative Peptide Names	Receptor-Type Tyrosine-Protein Phosphatase C protein Leukocyte Common Antigen protein L-Ca protein T200 protein Cd Antigen Cd45 protein PTPRC protein CD45 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance