Empire Genomics’ CDKN2B Break Apart FISH Probe is designed to flank the CDKN2B gene and is typically used for detecting CDKN2B rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Gene Summary

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: CDKN2B

Gene Name: Cyclin Dependent Kinase Inhibitor 2B

Chromosome: CHR9: 22002901-22009312

Locus: 9p21.3

References

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: CDKN2B FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CDKN2B-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping