Chicken TCRyd Antibody : Biotin
Référence OASB02396
Conditionnement : 0.5mg
Marque : Aviva Systems Biology
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Chicken TCRyd Antibody : Biotin (OASB02396)
| Datasheets/Manuals | Printable datasheet for Chicken TCRyd Antibody : Biotin (OASB02396) |
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| Tested Species Reactivity | Chicken |
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| Predicted Species Reactivity | Chicken |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | Biotin |
| Application | FC, IHC-F, IHC-P, IP |
| Additional Information | Description: The monoclonal antibody TCR-1 precipitates a heterodimer of Mr 90 kDa (two bands of Mr 50 kDa and 40 kDa upon reduction) on chicken peripheral blood T cells. Deglycosylation of the heterodimer yields two polypeptides of Mr 35 kDa and 32 kDa. Unlike human and mouse in which gamma/delta cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of gamma/delta T cells. The frequency of TCR gamma/delta cells is typically 20-25% of the total blood T cells but may reach approximately 50% in chickens of six- months of age. The majority of TCR gamma/delta+ cells in the thymus and blood are CD4-CD8- although a small subset of them may express CD8 or CD4 coreceptors. However, when the TCR gamma/delta+ cells migrate into the spleen and intestine most of them begin to express CD8. Although the biological function of gamma/delta T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ gamma/deta T cells may also be involved in down-regulation of the immune response. They cannot, however, induce a graft-vs-host (GVH) reactions. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Outbred chicken thymocytes and Ig-negative blood lymphocytes |
| Concentration | 0.5 mg/mL |
| Specificity | TCRgd |
