Colchicine-d3
Product Code
TRC-C640002
CAS Number
1217625-62-1
Product Format
Neat
Molecular Formula
C22 2H3 H22 N O6
Molecular Weight
402.46
Product Type
Stable Isotope LabelledUnlabelled CAS Number
64-86-8
Purity
>95% (HPLC)
Documentation
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Product Information
Chemical Data
Analyte Name
Colchicine 7-acetamide-d3
CAS Number
1217625-62-1
Molecular Formula
C22 2H3 H22 N O6
Molecular Weight
402.46
Accurate Mass
402.187
SMILES
[2H]C([2H])([2H])C(=O)N[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1/i1D3
IUPAC
2,2,2-trideuterio-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzopmheptalen-7-yl]acetamide
Unlabelled CAS Number
64-86-8
SIL Type
Deuterium
Product Data
Storage Temperature
-20°C
Shipping Temperature
Room Temperature
Country of Origin
CANADA
Product Type
Stable Isotope Labelled
Product Format
Neat
Purity
>95% (HPLC)
Product Description
An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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