Doublecortin (DCX) (NM_178151) Human Mass Spec Standard

Référence PH316349

Conditionnement : 10ug

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Doublecortin (DCX) (NM_178151) Human Mass Spec Standard

Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence [RC216349]
Predicted MW 40 kDa
Protein Sequence
Protein Sequence
>RC216349 protein sequence
Red=Cloning site Green=Tags(s)

MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVY
AVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTK
NVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQV
LTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSA
TAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSL
DDSDSLGDSM

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_835364
RefSeq Size 9262
RefSeq ORF 1080
Synonyms DBCN; DC; LISX; SCLH; XLIS
Locus ID 1641
UniProt ID O43602
Cytogenetics Xq23
Summary This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Protein Families Druggable Genome
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SKU Description Size
PH306454 DCX MS Standard C13 and N15-labeled recombinant protein (NP_835366) 10 ug
PH321891 DCX MS Standard C13 and N15-labeled recombinant protein (NP_835365) 10 ug
LC403598 DCX HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LC405947 DCX HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LC406000 DCX HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LC424646 DCX HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LC434187 DCX HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LY403598 Transient overexpression lysate of doublecortin (DCX), transcript variant 2 100 ug
LY405947 Transient overexpression lysate of doublecortin (DCX), transcript variant 4 100 ug
LY406000 Transient overexpression lysate of doublecortin (DCX), transcript variant 3 100 ug
LY424646 Transient overexpression lysate of doublecortin (DCX), transcript variant 1 100 ug
LY434187 Transient overexpression lysate of doublecortin (DCX), transcript variant 5 100 ug
TP306454 Recombinant protein of human doublecortin (DCX), transcript variant 3, 20 µg 20 ug
TP316349 Recombinant protein of human doublecortin (DCX), transcript variant 4, 20 µg 20 ug
TP321891 Recombinant protein of human doublecortin (DCX), transcript variant 2, 20 µg 20 ug
TP331188 Purified recombinant protein of Homo sapiens doublecortin (DCX), transcript variant 5, 20 µg 20 ug
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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