Doublecortin (DCX) (NM_178152) Human Mass Spec Standard
Product Images
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC221891 |
| Predicted MW | 40.4 kDa |
| Protein Sequence | >RC221891 representing NM_178152 Red=Cloning site Green=Tags(s) MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVY AVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTK NVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQV LTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSA TAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLY LPLSLDDSDSLGDSM TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Reference Data | |
| RefSeq | NP_835365 |
| RefSeq Size | 9069 |
| RefSeq ORF | 1095 |
| Synonyms | DBCN; DC; LISX; SCLH; XLIS |
| Locus ID | 1641 |
| UniProt ID | O43602 |
| Cytogenetics | Xq23 |
| Summary | This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
| Protein Families | Druggable Genome |
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Resources
Recombinant Protein Resources |
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| LC403598 | DCX HEK293T cell transient overexpression lysate (as WB positive control) | 134,00 EUR | |
| LC405947 | DCX HEK293T cell transient overexpression lysate (as WB positive control) | 134,00 EUR | |
| LC406000 | DCX HEK293T cell transient overexpression lysate (as WB positive control) | 134,00 EUR | |
| LC424646 | DCX HEK293T cell transient overexpression lysate (as WB positive control) | 206,00 EUR | |
| LC434187 | DCX HEK293T cell transient overexpression lysate (as WB positive control) | 134,00 EUR | |
| LY403598 | Transient overexpression lysate of doublecortin (DCX), transcript variant 2 | 436,00 EUR | |
| LY405947 | Transient overexpression lysate of doublecortin (DCX), transcript variant 4 | 436,00 EUR | |
| LY406000 | Transient overexpression lysate of doublecortin (DCX), transcript variant 3 | 436,00 EUR | |
| LY424646 | Transient overexpression lysate of doublecortin (DCX), transcript variant 1 | 665,00 EUR | |
| LY434187 | Transient overexpression lysate of doublecortin (DCX), transcript variant 5 | 436,00 EUR | |
| PH306454 | DCX MS Standard C13 and N15-labeled recombinant protein (NP_835366) | 3 255,00 EUR | |
| PH316349 | DCX MS Standard C13 and N15-labeled recombinant protein (NP_835364) | 3 255,00 EUR | |
| TP306454 | Recombinant protein of human doublecortin (DCX), transcript variant 3, 20 µg | 867,00 EUR | |
| TP316349 | Recombinant protein of human doublecortin (DCX), transcript variant 4, 20 µg | 867,00 EUR | |
| TP321891 | Recombinant protein of human doublecortin (DCX), transcript variant 2, 20 µg | 867,00 EUR | |
| TP331188 | Purified recombinant protein of Homo sapiens doublecortin (DCX), transcript variant 5, 20 µg | 867,00 EUR |