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> GS-441524 [1191237-69-0]

GS-441524 [1191237-69-0]

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GS-441524 | Remdesivir active metabolite

CAS:
1191237-69-0
Catalog Number:
10-4485
Activity:
Remdesivir active metabolite
Chemical Names:
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Molecular Weight:
291.27
Molecular Formula:
C12H13N5O4
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

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10 mg$30.00
50 mg$110.00
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GS-441524 (1191237-69-0) is the parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir.  Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.

References:

  1. Cho et al. (2012) Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides; Med. Chem. Lett. 22 2705
  2. Yan and Muller (2020) Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment; ACS Med. Chem. Lett. 11 1361
CAS:
1191237-69-0
Catalog Number:
10-4485
Activity:
Remdesivir active metabolite
Chemical Names:
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Molecular Weight:
291.27
Molecular Formula:
C12H13N5O4
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

GS-441524 (1191237-69-0) is the parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir.  Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolyzed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.

References:

  1. Cho et al. (2012) Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides; Med. Chem. Lett. 22 2705
  2. Yan and Muller (2020) Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment; ACS Med. Chem. Lett. 11 1361