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> Guinea Pig Polyclonal Anti-Perilipin 2 (N-terminus aa 1-29)

Guinea Pig Polyclonal Anti-Perilipin 2 (N-terminus aa 1-29)

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Conditionnement : 100µL

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anti-Perilipin 2 (N-terminus aa 1-29) guinea pig polyclonal, serum

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.
Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians.
Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.
Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C.
Datasheet
Quantity 100 µl
Antibody Type Polyclonal
Host Guinea pig
Conjugate Unconjugated
Application ICC/IF, IHC, WB
Purification Stabilized antiserum
Reactivity Human, Mouse
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Immunogen Synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin)
Formulation Contains 0.09% sodium azide
UniprotID Q99541 (Human), P43883 (Mouse)
Synonym Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP, PLIN2, ADFP
Note Centrifuge prior to opening
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:100-1:200
Immunohistochemistry (IHC) - paraffin 1:100-1:500 (microwave treatment recommended)
Western Blot (WB) 1:500-1:1,000

Perilipin 2/Adipophilin/ADRP/PLIN2 (a member of the PLIN/PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir.
Enhanced expression of Perilipin 2/Adipophilin/ADRP/PLIN2 is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis.
ADRP can also be used to study the virus entry via lipid droplets.
Polypeptide reacting: specific for Perilipin 2/Adipophilin/ADRP/PLIN2, MW 48,100 (calculated from aa sequence data); apparent Mr 52,000 (after SDS-PAGE); pI 6.72.
Immunolocalization: Adipophilin/PLIN2 is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculata of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative.
Also positively stained are lipid-storing CD 68-positive macrophages.


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