HSD17B4 Polyclonal Antibody, PE-Cy5 Conjugated
Référence bs-11296R-PE-Cy5
Conditionnement : 100ul
Marque : Bioss
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HSD17B4 Polyclonal Antibody, PE-Cy5 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11296R-PE-Cy5 |
| Product Name | HSD17B4 Polyclonal Antibody, PE-Cy5 Conjugated |
| Applications | WB |
| Reactivity | Mouse, Sheep, Zebrafish |
| Predicted Reactivity | Human, Rat, Cow, Pig, Horse, Chicken, Guinea Pig |
| Specifications | |
| Conjugation | PE-Cy5 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2 |
| Immunogen Range | 521-620/736 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Subcellular location | Cytoplasm |
| Synonyms | hydroxysteroid 17-beta dehydrogenase 4; 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 17 beta HSD 4; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogenase type IV; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody 3-alpha; 7-alpha; Beta hydroxyacyl dehydrogenase; Beta keto reductase; D 3 hydroxyacyl CoA dehydratase; D bunctional protein; D bunctional protein peroxisomal; D-bunctional protein; DBP; DHB4_HUMAN; EDH17B4; Enoyl-CoA hydratase 2; Hsd17b4; MFE 2; MFE-2; MPF-2; Multunctional protein 2; Peroxisomal multunctional enzyme type 2; Peroxisomal multunctional protein 2; SDR8C1; Short chain dehydrogenase/reductase family 8C member 1. |
| Background | 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period. |
| Application Dilution | |
| WB | 1:300-5000 |