Human Alpha-Synuclein Protein
Référence orb640151-1mg
Conditionnement : 1mg
Marque : Biorbyt
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Human Alpha-Synuclein Protein
Catalog Number: orb640151
| Catalog Number | orb640151 |
|---|---|
| Category | Proteins |
| Description | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. This chaperone activity is important to sustain normal SRE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
| Reactivity | Human |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 90% |
| Conjugation | Unconjugated |
| MW | 16.3 kDa |
| Target | Alpha-Synuclein |
| UniProt ID | P37840 |
| Protein Sequence | NP_000336.1 |
| Source | Human Alpha-Synuclein, His Tag (orb640151) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). |
| Expression System | E. coli |
| Biological Origin | Human |
| Expression Region | Met 1 - Ala 140 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_000336.1 |
| Storage | -20°C |
| Buffer/Preservatives | 100 mM NaAC, pH7.0 |
| Alternative names | SNCA,NACP,PARK1,alpha-Synuclein |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE). |
| Expiration Date | 6 months from date of receipt. |